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, out of order wifly city idu 2850ug 16grarrarNovel anti-hyperalgesic drug discovery in the neuropathic pain field: a systematic review. Neuropathic pain is a frequently encountered and, unfortunately, unresponsive clinical problem. Although effective treatments are available for patients with neuropathic pain, the treatments only alleviate the symptoms of the disease, and most patients continue to suffer from the disease. Many scientists consider the development of novel analgesics with new mechanisms of action to be a main objective of research in the field of analgesia. In this review, a selective search of PubMed for novel anti-hyperalgesic drugs used for the treatment of neuropathic pain is performed. Data were selected according to the analysis of the therapeutic activity of the drugs, their action mechanisms and their preclinical toxicity in various experimental models, including the neuropathic pain model. Data were then evaluated according to quality criteria and results were integrated and presented. The review indicates that one of the most promising therapeutic targets for the treatment of neuropathic pain is the pharmacologic inhibition of N-methyl-D-aspartate (NMDA) receptor subunits. Therefore, NMDA receptor antagonists appear to be a class of promising new anti-hyperalgesic drugs. They appear to be effective for the treatment of several forms of neuropathic pain. in the treatment of the patients included in this study. It is expected that the number of patients to be evaluated would be considerably increased in the next years. In conclusion, we demonstrated that the combination of the CDT-B (Mannitol, Ciprofloxacin, Ticarcillin/Clavulanate) 3 daily infusion with a six-week MV cycle improves clinical efficacy and reduces the occurrence of side effects in patients with refractory or relapsing UC. The use of the CDT-B combination in patients receiving 5-ASA and MTX, or in patients with chemotherapy-induced cytopenias, is well tolerated and provides good efficacy. Our findings suggest that this regimen could be useful in this setting. **CONFLICTS OF INTEREST** None. **FUNDING** The study was funded by Gilead. 5-ASA : 5-aminosalicylates CDT-B : Ciprofloxacin-tigecycline-tobram

 

 


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